3696-36-4

Usage

Uses

Used in Pharmaceutical Production:
2-Methylmalononitrile is utilized as a reactant in the synthesis of various pharmaceuticals. Its reactivity makes it a key component in the development of new drugs and medicines.
Used in Agricultural Chemicals Manufacturing:
2-METHYLMALONONITRILE also plays a role in the production of agricultural chemicals, contributing to the development of products that support crop protection and enhancement of agricultural yields.
Used in Dye and Pigment Industries:
2-Methylmalononitrile is employed as an intermediate in the manufacturing of dyes and pigments, where its chemical properties are leveraged to create a wide range of colorants for various applications.
Used as a Chemical Intermediate:
Beyond its direct applications, 2-Methylmalononitrile serves as an intermediate in the production of other chemical compounds, highlighting its importance in the broader scope of chemical manufacturing and innovation.

InChI:InChI=1/C9H8BNO2/c12-10(13)9-8-4-2-1-3-7(8)5-6-11-9/h1-6,12-13H

Upstream product

• 71565-78-1 2-cyanopropionamide 
• 1617-17-0 2-chlorpropionitrile 
• 57-12-5 cyanide^(1-) 
• 85688-94-4 (1,1-Dimethylpropyl)methylmalonsaeuredinitril 
• 85688-96-6 Methyl(1,1,2-trimethylpropyl)malonsaeuredinitril 
• 138976-63-3 methyliodomalononitrile 
• 50-00-0 formaldehyd 
• 109-77-3 malononitrile 
• 77928-77-9 2-methyl-1,4-butanediamide 
• 773837-37-9 sodium cyanide 
• 6839-20-9 2-[(methylsulfonyl)oxy]propanenitrile 
• 74-83-9 methyl bromide 
• 74-88-4 methyl iodide 
• 24850-33-7 allyltributylstanane 

Downstream Products

• 6802-57-9 9,10-dihydro-9,10-ethano-anthracene-11,11-dicarbonitrile 
• 2400-78-4 1,3-diamino-2-methylpropane 
• 89182-81-0 2-bromo-2-cyanopropionitrile 
• 162706-06-1 4,6-diamino-5-methyl-1H-pyrimidine-2-thione 
• 23054-41-3 methyl-(2,4,6-triphenyl-6H-[1,3]oxazin-6-yl)-malononitrile 
• 72632-65-6 4-methyl-5-aminothiazole 
• 7765-74-4 (2-cyano-1-chloro-propenyl)-phosphorimidic acid trichloride 
• 7713-07-7 1,1,2-Trichlor-2-cyan-N-trichlorphosphoronyliden-propylamin 
• 7713-03-3 2,2,4,6-tetrachloro-5-methyl-2λ⁵-[1,3,2]diazaphosphinine 
• 10517-95-0 Methylsulfonyl-methyl-malodinitril 
• 50997-04-1 p-Xylylenbis(methylmalonnitril) 
• 141439-28-3 2-Methyl-2-(phenylseleno)malononitrile 
• 116808-61-8 C₁₆H₃₆N⁽¹⁺⁾*C₄H₃N₂^(1-) 
• 120634-13-1 (E)-3-Amino-2-methyl-3-methylsulfanyl-acrylonitrile 

Relevant academic research and scientific papers

Copper-Catalyzed Cross-Nucleophile Coupling of β-Allenyl Silanes with Tertiary C-H Bonds: A Radical Approach to Branched 1,3-Dienes

Described herein is a distinctive approach to branched 1,3-dienes through oxidative coupling of two nucleophilic substrates, β-allenyl silanes, and hydrocarbons appending latent functionality by copper catalysis. Notably, C(sp3)-H dienylation proceeded in a regiospecific manner, even in the presence of competitive C-H bonds that are capable of occurring hydrogen atom transfer process, such as those located at benzylic and other tertiary sites, or adjacent to an oxygen atom. Control experiments support the intermediacy of functionalized alkyl radicals.

Corresponding amine nitrile and method of manufacturing thereof (by machine translation)

The present invention relates to a nitrile manufacturing method, which has characteristics of significantly-reduced ammonia source consumption, low environmental pressure, low energy consumption, low production cost, high nitrile purity, high nitrile yield and the like compared with the method in the prior art, wherein nitrile having a complicated structure can be obtained through the method. The present invention further relates to a method for producing a corresponding amine from the nitrile.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.

2 - methyl malonic acid diester synthetic method of the compound

The invention discloses a synthetic method of 2-diester methylmalonate compounds, and relates to the technical field of carboxylic ester preparation. The synthetic method comprises steps as follows: C, sulfonic acid 2-ethyl N-cyanoethanimideate IV and cyanide react under the action of a solvent and a catalyst, and 2-methyl malononitrile V is obtained; D, 2-methyl malononitrile V and ROH react under the action of the solvent and concentrated sulfuric acid, and products of 2-diester methylmalonate compounds I are obtained, wherein MCN is cyanide, M is Na or K, ROH is alkyl alcohol, alkenyl alcohol or a fluoride group containing alcohol, is benzyl alcohol or benzyl alkyl, halogen or nitro substituted benzyl alcohol, or is phenol or C1-C5 containing alkyl, halogen or nitro substituted phenol. The method is unique, the reaction conditions are mild, the reaction process is basically free of by-products, the yield is high, adopted raw materials have extensive sources, and acetaldehyde can be used as the raw material; the synthetic method is applicable to industrial production.

AlCl3 catalyzed coupling of: N-benzylic sulfonamides with 2-substituted cyanoacetates through carbon-nitrogen bond cleavage

A new cross-coupling reaction of N-benzylic sulfonamides with 2-substituted cyanoacetates for the synthesis of 2-substituted benzylbenzene was reported. In the presence of AlCl3, a broad range of N-benzylic sulfonamides reacted smoothly with 2-substituted cyanoacetates to afford structurally diverse benzylbenzenes in moderate to excellent yields. The conversion could be enlarged to gram-scale efficiently. The practicability of this approach was further manifested in the synthesis of a related bioactive agent with high anti-inflammatory activity.

Catalytic Anti-Markovnikov Transformations of Hindered Terminal Alkenes Enabled by Aldehyde-Selective Wacker-Type Oxidation

A new strategy for the functionalization of sterically hindered terminal olefins is reported. Alkenes bearing quaternary carbons at the allylic or homoallylic position are readily oxidized to the corresponding aldehydes by palladium/copper/nitrite catalysis. A broad range of functional groups including esters, nitriles, silyl ethers, vinylogous esters, ketones, lactones, and β-ketoesters are tolerated under the reaction conditions. The crude aldehyde products can be transformed further, enabling direct conversion of hindered terminal alkenes to various other synthetically useful functional groups, resulting in formal anti-Markovnikov hydroamination, among other transformations.

A route to highly functionalized-enaminoesters via a domino ring-opening cyclization/decarboxylative tautomerization sequence of donor-acceptor cyclopropanes with substituted malononitriles

An unprecedented and domino synthetic strategy for the synthesis of highly functionalized carbocyclic-enaminoesters bearing an all-carbon quaternary center via Yb(OTf)3-catalyzed ring-opening cyclization/decarboxylative tautomerization of donor-acceptor cyclopropanes with 2-alkyl malononitriles in excellent yields is described. The products are obtained as a single diastereomer in most cases where the nitrile and aryl groups are aligning in a cis orientation across the ring.

NOVEL TARGETING AGENTS FOR DIAGNOSTIC AND THERAPEUTIC INDICATIONS

The invention relates to compounds and use thereof in the diagnosis and/or in treatment of medical disorders. In some embodiments, the compounds may be used for detecting a cancer. The compound may include a di-acid moiety. In some embodiments the di-acid moiety comprises a di-carboxylic acid and in some embodiments the di- acid moiety comprises a di-tetrazole.

Tetrapodal amidoxime ligands I. Coordination isomerism due to self-complementary dimerization of a pyramidal cobalt(iii) coordination module

A bis-μ-amidoximato-bridged cobalt(iii) dimer obtained with a new tetrapodal ligand possesses interesting structural parameters as a consequence of intramolecular hydrogen bonding intentionally built into the complex. Its synthesis and properties are described. The new ligand type combines attributes of two previously described ligand classes: It binds a metal ion in a tetrapodal pentadentate fashion and forms a pseudomacrocycle through hydrogen bonds, characteristic of chelating oxime ligands. Coordination isomerism, which is a consequence of dimer formation, has been analyzed by means of X-ray crystallography and carbon-13 nuclear magnetic resonance spectroscopy. The Royal Society of Chemistry 2012.