Technology Process of (S)-2-amino-2-methyl-7-phenylheptanoic acid
There total 8 articles about (S)-2-amino-2-methyl-7-phenylheptanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H21NO3;
With
bromine; sodium hydroxide;
In
water;
at 0 - 75 ℃;
for 4.5h;
With
hydrogenchloride;
In
water;
DOI:10.1016/j.tet.2011.05.103
- Guidance literature:
-
Multi-step reaction with 5 steps
1: water / N,N-dimethyl-formamide / 1.5 h / 30 °C / pH 7 / potassium phosphate buffer; Microbiological reaction; Enzymatic reaction
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / Inert atmosphere; Reflux
4: palladium 10% on activated carbon; hydrogen / methanol
5: bromine; sodium hydroxide / water / 4.5 h / 0 - 75 °C
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; water; hydrogen; bromine; potassium carbonate; sodium hydroxide;
In
methanol; water; N,N-dimethyl-formamide; toluene;
5: Hofmann rearrangement;
DOI:10.1016/j.tet.2011.05.103
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dihydrogen peroxide / basic conditions
2: water / N,N-dimethyl-formamide / 1.5 h / 30 °C / pH 7 / potassium phosphate buffer; Microbiological reaction; Enzymatic reaction
3: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / Inert atmosphere; Reflux
5: palladium 10% on activated carbon; hydrogen / methanol
6: bromine; sodium hydroxide / water / 4.5 h / 0 - 75 °C
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; water; hydrogen; dihydrogen peroxide; bromine; potassium carbonate; sodium hydroxide;
In
methanol; water; N,N-dimethyl-formamide; toluene;
6: Hofmann rearrangement;
DOI:10.1016/j.tet.2011.05.103
