C₂₇H₂₇N₇O₂

Base Information

• Chemical Name: C₂₇H₂₇N₇O₂
• CAS No.: 1421373-89-8
• Molecular Formula: C₂₇H₂₇N₇O₂
• Molecular Weight: 481.557
• Mol file: 1421373-89-8.mol

Synonyms:C₂₇H₂₇N₇O₂

Chemical Property of C₂₇H₂₇N₇O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₇N₇O₂

There total 8 articles about C₂₇H₂₇N₇O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl}benzene-1,3-diamine (1421373-14-9) + acryloyl chloride (814-68-6,25189-84-8) → C27H27N7O2 (1421373-89-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -5 - 0 ℃; for 0.516667h; Inert atmosphere;

Reference yield:

2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroaniline (1421371-96-1) → C27H27N7O2 (1421373-89-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 4 h / Inert atmosphere; Reflux

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

3: triethylamine / tetrahydrofuran / 0.52 h / -5 - 0 °C / Inert atmosphere

With iron; ammonium chloride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; water;

Reference yield:

4-bromo-2-methoxy-5-nitrobenzenamine (1421371-97-2) → C27H27N7O2 (1421373-89-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 2 h / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / 4 h / Inert atmosphere; Reflux

3: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

4: triethylamine / tetrahydrofuran / 0.52 h / -5 - 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

upstream raw materials:

2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroaniline

4-bromo-2-methoxy-5-nitrobenzenamine

4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl}benzene-1,3-diamine

acryloyl chloride