2-methoxy-5-nitro-4-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)benzenamine

Base Information

• Chemical Name: 2-methoxy-5-nitro-4-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)benzenamine
• CAS No.: 1421371-96-1
• Molecular Formula: C₁₃H₁₇N₃O₃
• Molecular Weight: 263.296
• Mol file: 1421371-96-1.mol

Synonyms:2-methoxy-5-nitro-4-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)benzenamine

Chemical Property of 2-methoxy-5-nitro-4-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)benzenamine

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-methoxy-5-nitro-4-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)benzenamine

There total 2 articles about 2-methoxy-5-nitro-4-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl )-1,2,3,6-tetrahydropyridine (454482-11-2) + 4-bromo-2-methoxy-5-nitrobenzenamine (1421371-97-2) → 2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroaniline (1421371-96-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 2h; Inert atmosphere; Reflux;

Reference yield:

4-bromo-2-methoxyaniline (59557-91-4) → 2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroaniline (1421371-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; guanidine nitrate / water / 0.92 h / 0 - 5 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 2 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; guanidine nitrate; potassium carbonate; In 1,4-dioxane; water;

Reference yield: 72.0%

3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine (1224709-13-0) + 2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroaniline (1421371-96-1) → 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine (1421372-22-6)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; for 1h; Cooling with ice;

upstream raw materials:

1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl )-1,2,3,6-tetrahydropyridine

4-bromo-2-methoxy-5-nitrobenzenamine

4-bromo-2-methoxyaniline

Downstream raw materials:

C₂₇H₂₇N₇O₂

6-methoxy-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{5-methyl-4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl}benzene-1,3-diamine

4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl}benzene-1,3-diamine

N'-{4-[1-(benzenesulfonyl)indol-3-yl]-5-chloropyrimidin-2-yl}-4-methoxy-6-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)benzene-1,3-diamine

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