1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

Base Information

Chemical Name:1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one
CAS No.:1236352-61-6
Molecular Formula:C₂₂H₂₄N₂O₄
Molecular Weight:382.433
Hs Code.:

Synonyms:1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

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Chemical Property of 1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

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Technology Process of 1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

There total 5 articles about 1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1236352-59-2
4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}(formyl-14C)benzaldehyde

: 1236352-61-6
1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In benzene; for 1h; Reflux; Inert atmosphere;
DOI:10.1002/jlcr.1755

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1313188-69-0
ethyl 2-benzoyl-5-(4-bromophenyl)pent-4-ynoate

: 1236352-62-7
di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

: 1236352-61-6
1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 4 h / -40 °C

1.2: 2.25 h / -40 - 20 °C

1.3: 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: triethylsilane; bis-triphenylphosphine-palladium(II) chloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; lithium chloride / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride; acetic acid / benzene / 1 h / Reflux; Inert atmosphere

5.1: 1H-tetrazole / dichloromethane

5.2: 0 - 20 °C

6.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C / Saturated solution

With 1H-tetrazole; hydrogenchloride; triethylsilane; bis-triphenylphosphine-palladium(II) chloride; isopropylmagnesium chloride; acetic anhydride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1002/jlcr.1755

Reference yield:

: 1236352-60-5
4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}(carboxy-14C)benzoic acid

: 1236352-61-6
1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

Guidance literature:: 4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}(carboxy-14C)benzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 1,2-dimethoxyethane; at 0 - 20 ℃; for 16h;

With palladium 10% on activated carbon; hydrogen; In 1,2-dimethoxyethane; for 1h;
DOI:10.1002/jlcr.1755