(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate

Base Information

Chemical Name:(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate
CAS No.:1236352-63-8
Molecular Formula:C₂₂H₂₅N₂O₇P
Molecular Weight:462.412
Hs Code.:

Synonyms:(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate

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Chemical Property of (4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate

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Technology Process of (4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate

There total 7 articles about (4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 86-74-8,105184-46-1,97960-57-1
9H-carbazole

: 785051-54-9
9-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9H-carbazole

: 1352441-06-5
trimethyl((4-(pent-1-ynyl)phenyl)ethynyl)silane

: 1-allyl-4-iodobenzene

: 1280227-57-7
5,10,15,20-tetra(p-tolyl)porphyrinato-iridium(III)-p-bromophenyl

: 1236352-63-8
(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 85 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 6 h / 80 °C

With tri-tert-butyl phosphine; potassium tert-butylate; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dimethyl sulfoxide; toluene;

Reference yield:

: 1236352-62-7
di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

: 1236352-63-8
(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h; Saturated solution;
DOI:10.1002/jlcr.1755

Reference yield:

: 1236352-57-0
(4-bromophenyl)(6-methoxy-1H-indazol-3-yl)methanone

: 1236352-63-8
(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-carbonyl}phenyl)(14C)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2.1: triethylsilane; bis-triphenylphosphine-palladium(II) chloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; lithium chloride / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride; acetic acid / benzene / 1 h / Reflux; Inert atmosphere

4.1: 1H-tetrazole / dichloromethane

4.2: 0 - 20 °C

5.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C / Saturated solution

With 1H-tetrazole; hydrogenchloride; triethylsilane; bis-triphenylphosphine-palladium(II) chloride; acetic anhydride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1002/jlcr.1755