di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

Base Information

Chemical Name:di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate
CAS No.:1236352-62-7
Molecular Formula:C₃₀H₄₁N₂O₇P
Molecular Weight:574.627
Hs Code.:

Synonyms:di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

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Chemical Property of di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

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Technology Process of di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

There total 7 articles about di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1313188-69-0
ethyl 2-benzoyl-5-(4-bromophenyl)pent-4-ynoate

: 1236352-62-7
di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 4 h / -40 °C

1.2: 2.25 h / -40 - 20 °C

1.3: 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: triethylsilane; bis-triphenylphosphine-palladium(II) chloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; lithium chloride / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride; acetic acid / benzene / 1 h / Reflux; Inert atmosphere

5.1: 1H-tetrazole / dichloromethane

5.2: 0 - 20 °C

6.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C / Saturated solution

With 1H-tetrazole; hydrogenchloride; triethylsilane; bis-triphenylphosphine-palladium(II) chloride; isopropylmagnesium chloride; acetic anhydride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1002/jlcr.1755

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1313188-69-0
ethyl 2-benzoyl-5-(4-bromophenyl)pent-4-ynoate

: 1236352-62-7
di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

: 1236352-61-6
1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 4 h / -40 °C

1.2: 2.25 h / -40 - 20 °C

1.3: 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: triethylsilane; bis-triphenylphosphine-palladium(II) chloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; lithium chloride / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride; acetic acid / benzene / 1 h / Reflux; Inert atmosphere

5.1: 1H-tetrazole / dichloromethane

5.2: 0 - 20 °C

6.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C / Saturated solution

With 1H-tetrazole; hydrogenchloride; triethylsilane; bis-triphenylphosphine-palladium(II) chloride; isopropylmagnesium chloride; acetic anhydride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1002/jlcr.1755

Reference yield:

: 1236352-61-6
1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

: 1236352-62-7
di-tert-butyl(4-{[1-(3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}phenyl)(14C)methyl phosphate

Guidance literature:: 1-[3-({4-[hydroxy(14C)methyl]phenyl}carbonyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one; di-tert-butyl N,N-diethylphosphoramidite; With 1H-tetrazole; In dichloromethane;

With tert.-butylhydroperoxide; at 0 - 20 ℃;
DOI:10.1002/jlcr.1755