(E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide

Base Information

Chemical Name:(E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide
CAS No.:484065-84-1
Molecular Formula:C₂₆H₃₁N₃O₅S
Molecular Weight:497.615
Hs Code.:

Synonyms:(E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide

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Chemical Property of (E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide

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Technology Process of (E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide

There total 3 articles about (E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 484065-83-0
(E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)ethenesulfonamide

: 74-88-4
methyl iodide

: 484065-84-1
(E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(02)00106-2

Reference yield:

: 138227-63-1
tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

: 484065-84-1
(E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; 4-dimethylaminopyridine / CH₂Cl₂ / 20 h / 20 °C

2: 0.35 g / triphenylphosphine; triethylamine; palladium(II) acetate / dimethylformamide / 17 h / 140 °C

3: 70 percent / potassium carbonate / dimethylformamide / 1 h / 20 °C

With pyridine; dmap; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 2: Heck reaction;
DOI:10.1016/S0968-0896(02)00106-2

Reference yield:

: 484065-66-9
N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}ethenesulfonamide

: 484065-84-1
(E)-N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-2-(3-cyanophenyl)-N-methylethenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.35 g / triphenylphosphine; triethylamine; palladium(II) acetate / dimethylformamide / 17 h / 140 °C

2: 70 percent / potassium carbonate / dimethylformamide / 1 h / 20 °C

With palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/S0968-0896(02)00106-2