4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester
• CAS No.: 143603-98-9
• Molecular Formula: C₁₈H₁₆N₄O₃
• Molecular Weight: 336.35

Synonyms:4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester

Chemical Property of 4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester

There total 2 articles about 4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-Aminoindole-2-carbohydrazide (110963-29-6) + methyl 4-formylbenzoate (1571-08-0) → 4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester (143603-98-9)

Guidance literature:

In ethanol; for 0.166667h; Heating;

DOI:10.1002/ardp.19923250712

Reference yield:

ethyl 3-amino-1H-indole-2-carboxylate (87223-77-6) → 4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester (143603-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / hydrazine hydrate / 4 h / Heating

2: 81 percent / ethanol / 0.17 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1002/ardp.19923250712

Reference yield: 79.0%

4-[(3-Amino-1H-indole-2-carbonyl)-hydrazonomethyl]-benzoic acid methyl ester (143603-98-9) → 4-{[(E)-4-Oxo-4,5-dihydro-[1,2,3]triazino[5,4-b]indol-3-ylimino]-methyl}-benzoic acid methyl ester (139953-78-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; for 5h; Ambient temperature;

DOI:10.1002/ardp.19923250712

upstream raw materials:

3-Aminoindole-2-carbohydrazide

methyl 4-formylbenzoate

ethyl 3-amino-1H-indole-2-carboxylate

Downstream raw materials:

4-{[(E)-4-Oxo-4,5-dihydro-[1,2,3]triazino[5,4-b]indol-3-ylimino]-methyl}-benzoic acid methyl ester

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