3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester

Base Information

• Chemical Name: 3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester
• CAS No.: 98874-13-6
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.315
• Mol file: 98874-13-6.mol

Synonyms:3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester

Chemical Property of 3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester

There total 4 articles about 3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-pyridinecarbonyl chloride (10400-19-8) + methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → 3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester (98874-13-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/om300610j

Reference yield:

pyridine-4-carboxylic acid (55-22-1) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → 3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester (98874-13-6)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1016/j.bmc.2011.08.001

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + isonicotinoyl chloride hydrochloride (39178-35-3) → 3-phenyl-2-[(pyridine-4-carbonyl)amino]propionic acid methyl ester (98874-13-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1021/ic200252z

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

isonicotinoyl chloride hydrochloride

pyridine-4-carboxylic acid

3-pyridinecarbonyl chloride

Downstream raw materials:

N-(N-4-pyridinylformyl-L-phenylalanyl)-L-phenylalanine methyl ester

N-(N-4-pyridinylformyl-L-phenylalanyl)-4-nitro-L-phenylalanine methyl ester

N-(N-4-pyridinylformyl-L-phenylalanyl)-L-tyrosine methyl ester

N-(N-4-pyridinylformyl-L-phenylalanyl)-L-phenylalanol