4-Aminophenol hydrochloride

Base Information

• Chemical Name: 4-Aminophenol hydrochloride
• CAS No.: 51-78-5
• Molecular Formula: C6H7NO^.HCl
• Molecular Weight: 145.589
• Hs Code.: 29222900
• European Community (EC) Number: 200-122-6
• UNII: IWL2N22RFY
• DSSTox Substance ID: DTXSID6058760
• Wikidata: Q27280927
• ChEMBL ID: CHEMBL388353
• Mol file: 51-78-5.mol

Synonyms:4-aminophenol;4-aminophenol conjugate monoacid;4-aminophenol hydrochloride;4-aminophenol monopotassium salt;4-aminophenol monosodium salt;4-aminophenol sulfate;4-aminophenol sulfate (2:1);4-aminophenol, 18O-labeled;4-aminophenol, 3H-labeled;4-aminophenol, ion(1+);4-hydroxyaniline;p-aminophenol;p-aminophenol phosphate;para-aminophenol

Chemical Property of 4-Aminophenol hydrochloride

Chemical Property:

• Appearance/Colour: Off white powder
• Vapor Pressure: 0.00202mmHg at 25°C
• Melting Point: 302 °C
• Boiling Point: 282 °C at 760 mmHg
• Flash Point: 124.3 °C
• PSA: 46.25000
• Density: 1.21g/cm3
• LogP: 2.35760
• Storage Temp.: Store below +30°C.
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 145.0294416
• Heavy Atom Count: 9
• Complexity: 66.9

Purity/Quality:

99% ^*data from raw suppliers

4-Aminophenol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 28-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amino Phenols
• Canonical SMILES: C1=CC(=CC=C1N)O.Cl
• Uses: 4-Aminophenol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using surface enhanced Raman scattering method.

Technology Process of 4-Aminophenol hydrochloride

There total 6 articles about 4-Aminophenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → p-aminophenol hydrochloride (51-78-5)

Guidance literature:

4-nitro-phenol; With sodium tetrahydroborate; water; at 20 ℃; for 2h;

With hydrogenchloride; In ethyl acetate;

DOI:10.1039/c6gc00222f

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + α-methylsuccinic di-p-anisidine (78533-09-2) → methylene chloride (74-87-3) + 2-methylbutanedioic acid (498-21-5,636-60-2) + p-aminophenol hydrochloride (51-78-5)

Guidance literature:

at 100 ℃;

Reference yield:

C18H29B2NO5 → p-aminophenol hydrochloride (51-78-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 20 ℃; for 1h;

DOI:10.1002/adsc.202101043

upstream raw materials:

hydrogenchloride

5-amino-2-hydroxybenzenesulfonic acid

α-methylsuccinic di-p-anisidine

4-amino-phenol

Downstream raw materials:

2,5-dimethyl-[1,4]benzoquinone-mono-(4-hydroxy-phenylimine)

2-((4-hydroxyphenyl)amino)acetonitrile

4-[(7-chloroquinolin-4-yl)amino]phenol

4-(7-chloro-2-methyl-quinolin-4-ylamino)-phenol

Refernces

• 1、 Yang, Fan,Chi, Cheng,Wang, Chunxia,Wang, Ying,Li, Yongfeng. "High graphite N content in nitrogen-doped graphene as an efficient metal-free catalyst for reduction of nitroarenes in water". supporting information. p. 4254 - 4262. Retrieved 2016/08/02.