1-(2-AMino-6-chloropurin-9-yl)ethanone

Base Information

• Chemical Name: 1-(2-AMino-6-chloropurin-9-yl)ethanone
• CAS No.: 470483-92-2
• Molecular Formula: C₇H₆ClN₅O
• Molecular Weight: 211.611
• Mol file: 470483-92-2.mol

Synonyms:9-acetyl-2-amino-6-chloro-9H-purine

Chemical Property of 1-(2-AMino-6-chloropurin-9-yl)ethanone

Chemical Property:

Purity/Quality:

1-(2-amino-6-chloro-9H-purin-9-yl)-Ethanone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-AMino-6-chloropurin-9-yl)ethanone

There total 2 articles about 1-(2-AMino-6-chloropurin-9-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Amino-6-chloropurin (10310-21-1) → 9-acetyl-2-amino-6-chloro-9H-purine (470483-92-2)

Guidance literature:

With acetic anhydride; triethylamine; In isopropyl alcohol; toluene;

Reference yield: 99.0%

acetic anhydride (108-24-7) + 2-amino-6-chloropurine (10310-21-1) → 9-acetyl-2-amino-6-chloro-9H-purine (470483-92-2)

Guidance literature:

In ISOPROPYLAMIDE; at 50 - 60 ℃; for 4h;

Reference yield: 78.3%

9-acetyl-2-amino-6-chloro-9H-purine (470483-92-2) → 2,6-dichloro-7H-purine (5451-40-1)

Guidance literature:

9-acetyl-2-amino-6-chloro-9H-purine; With chloro-trimethyl-silane; tetraethylammonium chloride; isopentyl nitrite; at 50 - 60 ℃; for 10h;

With sodium hydroxide; In water; pH=4 - 5; Product distribution / selectivity;

upstream raw materials:

acetic anhydride

2-amino-6-chloropurine

2-Amino-6-chloropurin

Downstream raw materials:

2,6-dichloro-7H-purine

2-bromo-6-chloro-7H-purine

6-chloro-2-iodo-(9H)-purine