L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate

Base Information

• Chemical Name: L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate
• CAS No.: 63229-05-0
• Molecular Formula: C₂HF₃O₂*C₁₈H₂₆N₄O₅S
• Molecular Weight: 524.518
• Mol file: 63229-05-0.mol

Synonyms:L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate

Chemical Property of L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate

There total 5 articles about L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Nα-tert-Butyloxycarbonyl-L-methionyl-L-aspartyl-L-phenylalanine amide (5920-14-9) + trifluoroacetic acid (76-05-1) → L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate (63229-05-0)

Guidance literature:

With methoxybenzene; at 20 ℃; for 2h;

DOI:10.1007/BF00757956

Reference yield:

N-benzyloxycarbonyl-aspartyl-phenylalanine amide (1947-39-3) → L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate (63229-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous ammonia, H₂ / Pd

2: diisopropylethylamine / dimethylformamide / 20 h / Ambient temperature

3: ethanedithiol / 0.25 h / Ambient temperature

With ethandithiol; ammonium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium; In N,N-dimethyl-formamide;

Reference yield:

Asp-Phe-NH2 (5241-71-4) → L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate (63229-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropylethylamine / dimethylformamide / 20 h / Ambient temperature

2: ethanedithiol / 0.25 h / Ambient temperature

With ethandithiol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

upstream raw materials:

N^α-tert-Butyloxycarbonyl-L-methionyl-L-aspartyl-L-phenylalanine amide

trifluoroacetic acid

N-Boc methionine pentafluorophenol ester

Asp-Phe-NH₂

Downstream raw materials:

N^α-tert-Butyloxycarbonyl-L-alanyl-L-methionyl-L-aspartyl-L-phenylalanine amide

(S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

N^α,δ-Di-tert-butyloxycarbonyl-L-ornithyl-L-methionyl-L-aspartyl-L-phenylalanine amide

N^α,δ-Di-tert-butyloxycarbonyl-D-ornithyl-L-methionyl-L-aspartyl-L-phenylalanine amide