3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester

Base Information

Chemical Name:3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester
CAS No.:261786-25-8
Molecular Formula:C₂₅H₃₂N₂O₆
Molecular Weight:456.539
Hs Code.:

Synonyms:3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester

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Chemical Property of 3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester

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Technology Process of 3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester

There total 8 articles about 3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2018-66-8
Z-Leu-OH

: 209174-37-8
3(S)-amino-2(R,S)-hydroxy-4-phenylbutyric acid methyl ester

: 261786-25-8
3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0301336

Reference yield:

: 209173-80-8
2(RS)-hydroxy-3(S)-amino-4-phenylbutanoic acid

: 261786-25-8
3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 20 °C

2: 92 percent / EDC; HOBT; NMM / dimethylformamide / 20 °C

With 4-methyl-morpholine; thionyl chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm0301336

Reference yield:

: 191849-93-1
3(S)-(N-tert-butoxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyric acid

: 261786-25-8
3(S)-(N-Cbz-leucylamino)-2(R,S)-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / methanol / 2 h / 20 °C

2: SOCl₂ / 20 °C

3: 92 percent / EDC; HOBT; NMM / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0301336