1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide

Base Information

• Chemical Name: 1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide
• CAS No.: 1088991-24-5
• Molecular Formula: Br*C₁₃H₁₇OS
• Molecular Weight: 301.247
• Mol file: 1088991-24-5.mol

Synonyms:1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide

Chemical Property of 1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide

There total 1 articles about 1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

sulfure de pentamethylene (1613-51-0) + α-bromoacetophenone (70-11-1) → 1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide (1088991-24-5)

Guidance literature:

In acetone; at 20 ℃; for 5h;

DOI:10.1021/acs.orglett.0c02747

Reference yield: 72.0%

N-((trifluoromethyl)thio)isoindoline-1,3-dione (719-98-2) + 1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide (1088991-24-5) → (E)-(2-chloro-1-((5-chloropentyl)thio)-2-phenylvinyl)(trifluoromethyl)sulfane + (Z)-(2-chloro-1-((5-chloropentyl)thio)-2-phenylvinyl)(trifluoromethyl)sulfane

Guidance literature:

With P,P-dichlorophenylphosphine oxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; stereoselective reaction; Molecular sieve; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.0c02747

Reference yield: 64.0%

1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide (1088991-24-5) + 1-[2-diazo-3-(triisopropylsilyloxy)but-3-enoyl]pyrrolidin-2-one → 8-[(5-bromopentyl)thio]-7-phenyl-6-(triisopropylsilyloxy)-2,3-dihydroindolizin-5(1H)-one

Guidance literature:

1-(2-oxo-2-phenylethyl)hexahydrothiopyrylium bromide; With tetrakis(acetonitrile)copper(I)tetrafluoroborate; triethylamine; In chloroform; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

1-[2-diazo-3-(triisopropylsilyloxy)but-3-enoyl]pyrrolidin-2-one; In chloroform; at 0 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201805323

upstream raw materials:

sulfure de pentamethylene

α-bromoacetophenone

Downstream raw materials:

C₂₁H₂₁BrO₂S

C₂₁H₂₁BrO₂S