1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea

Base Information

Chemical Name:1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea
CAS No.:1428156-92-6
Molecular Formula:C₁₇H₁₉F₃N₂O
Molecular Weight:324.346
Hs Code.:

Synonyms:1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea

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Technology Process of 1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea

There total 2 articles about 1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 402-43-7
p-trifluoromethylphenyl bromide

: 1428156-86-8
1-(but-3-yn-1-yl)-1-cyclopropyl-3,3-dimethylurea

: 1428156-92-6
1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ja401936c

Reference yield:

: 1181225-90-0
C₇H₁₁N

: 1428156-92-6
1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 18 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja401936c

Reference yield: 82.0%

: 201230-82-2
carbon monoxide

: 1428156-92-6
1-cyclopropyl-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)urea

: 1428156-98-2
N,N-dimethyl-5-oxo-4-(4-(trifluoromethyl)phenyl)-2,3,5,6,7,7a-hexahydro-1H-indole-1-carboxamide

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; tris<3,5-bis(trifluoromethyl)phenyl>phosphane; In benzonitrile; at 130 ℃; for 32h; under 760.051 Torr; Reagent/catalyst; Inert atmosphere;
DOI:10.1016/j.tet.2015.08.052