(+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide

Base Information

• Chemical Name: (+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide
• CAS No.: 349081-36-3
• Molecular Formula: C₁₆H₁₆BrNO
• Molecular Weight: 318.213
• Mol file: 349081-36-3.mol

Synonyms:(+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide

Chemical Property of (+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide

There total 5 articles about (+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-phenylpropionyl chloride (25145-43-1,36240-11-6,59981-93-0,22414-26-2) + 2-bromo-N-methylaniline (6832-87-7) → (+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide (349081-36-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/jo005761z

Reference yield:

C15H14BrNO (925699-40-7) + methyl iodide (74-88-4) → (+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide (349081-36-3)

Guidance literature:

C₁₅H₁₄BrNO; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

DOI:10.1021/ol200149s

Reference yield:

phenylacetic acid (103-82-2) → (+/-)-N-(2-bromophenyl)-N-methyl-2-phenylpropamide (349081-36-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 - 0 °C

2.1: thionyl chloride / 2 h / Reflux

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

4.2: 0 - 20 °C

With thionyl chloride; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1021/ol200149s

upstream raw materials:

2-phenylpropionyl chloride

2-bromo-N-methylaniline

phenylacetic acid

C₁₅H₁₄BrNO

Downstream raw materials:

1,3-dimethyl-3-phenylindolin-2-one

N-methyl-2,N-diphenylpropionamide