2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone

Base Information

Chemical Name:2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone
CAS No.:150208-68-7
Molecular Formula:C₁₆H₂₀Cl₂N₂O
Molecular Weight:327.254
Hs Code.:

Synonyms:2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone

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Technology Process of 2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone

There total 5 articles about 2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4430-75-5,96606-12-1
octahydro-1H-pyrido[1,2-a]pyrazine

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 150208-68-7
2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone

Guidance literature:: With dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂;
DOI:10.1021/jm00068a007

Reference yield:

: N-tBOC-pipecolinic acid

: 150208-68-7
2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, HOBT monohydrate, Et₃N / 24 h / Ambient temperature

2: 1 h / Ambient temperature

3: 55 percent / Et₃N / methanol / Heating

4: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

5: 1.) DCC / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00068a007

Reference yield:

: 2,2-Dimethyl-propionic acid 2-(methoxycarbonylmethyl-carbamoyl)-piperidin-1-yl ester

: 150208-68-7
2-(3,4-Dichloro-phenyl)-1-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1 h / Ambient temperature

2: 55 percent / Et₃N / methanol / Heating

3: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

4: 1.) DCC / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂

With lithium aluminium tetrahydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00068a007