Methyl (3-fluoro-4-hydroxyphenyl)acetate

Base Information

• Chemical Name: Methyl (3-fluoro-4-hydroxyphenyl)acetate
• CAS No.: 79280-92-5
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.167
• Hs Code.: 2918290090
• European Community (EC) Number: 860-552-0
• Mol file: 79280-92-5.mol

Synonyms:Methyl (3-fluoro-4-hydroxyphenyl)acetate;79280-92-5;methyl 2-(3-fluoro-4-hydroxyphenyl)acetate;methyl 3-fluoro-4-hydroxyphenylacetate;(3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester;Methyl 2-(3-fluoro-4-hydroxy-phenyl)acetate;SCHEMBL926809;AXONPFSLAZILIE-UHFFFAOYSA-N;MFCD18399290;AKOS022641533;AS-8594;Methyl(3-fluoro-4-hydroxyphenyl)acetate;CS-0233022;EN300-130147;3-Fluoro-4-hydroxybenzeneacetic acid methyl ester;Z1255453601;3-Fluoro-4-hydroxyphenylacetic acid methyl ester, 2-Fluoro-4-(2-methoxy-2-oxoethyl)phenol

Chemical Property of Methyl (3-fluoro-4-hydroxyphenyl)acetate

Chemical Property:

• Boiling Point: 90-93 °C(Press: 13.3 Torr)
• Density: 1.271±0.06 g/cm3(Predicted)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 184.05357231
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-Fluoro-4-hydroxyphenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)CC1=CC(=C(C=C1)O)F

Technology Process of Methyl (3-fluoro-4-hydroxyphenyl)acetate

There total 9 articles about Methyl (3-fluoro-4-hydroxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (3-fluoro-4-hydroxyphenyl)acetic acid (458-09-3) → (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester (79280-92-5)

Guidance literature:

With sulfuric acid; at 68 ℃; for 2h;

Reference yield: 97.6%

(3-fluoro-4-hydroxyphenyl)acetic acid (458-09-3) → (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester (79280-92-5)

Guidance literature:

sulfuric acid; In methanol;

Reference yield: 64.7%

(3-fluoro-4-hydroxyphenyl)acetic acid (458-09-3) + diazomethyl-trimethyl-silane (18107-18-1) → (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester (79280-92-5)

Guidance literature:

With methanol; In tetrahydrofuran; for 1h;

upstream raw materials:

methanol

(3-fluoro-4-hydroxyphenyl)acetic acid

Methyl 4-hydroxyphenylacetate

diazomethyl-trimethyl-silane

Downstream raw materials:

methyl 2-(4-(4-((4-chlorophenethyl)carbamoyl)-2-nitrophenoxy)-3-fluorophenyl)acetate

2-(methylamino)-4-(2-{4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)benzonitrile

2-(methylthio)-4-(2-{4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)benzonitrile