methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

Base Information

• Chemical Name: methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate
• CAS No.: 1214996-54-9
• Molecular Formula: C₂₂H₁₈ClIN₂O₄
• Molecular Weight: 536.753

Synonyms:methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

Chemical Property of methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

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Technology Process of methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

There total 1 articles about methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 2-[[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl](hydroxy)methyl]acrylate (1214996-51-6) + acetyl chloride (75-36-5) → methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-54-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/adsc.200900438

Reference yield: 85.0%

methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-54-9) → methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-57-2)

Guidance literature:

methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃; for 0.25h;

With sodium tetrahydroborate; In tetrahydrofuran; water; at 5 - 20 ℃;

DOI:10.1002/adsc.200900438

Reference yield: 72.0%

indole (120-72-9) + methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-54-9) → methyl (E)-3-(5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl)-2-((1H-indol-1-yl)methyl)prop-2-enoate

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; stereoselective reaction;

DOI:10.1002/ejoc.201200401

upstream raw materials:

methyl 2-[[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl](hydroxy)methyl]acrylate

acetyl chloride

Downstream raw materials:

methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

C₂₀H₁₇ClIN₃O₂

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