3-Methoxy-5-nitropyridin-2-ol

Base Information

• Chemical Name: 3-Methoxy-5-nitropyridin-2-ol
• CAS No.: 75710-99-5
• Molecular Formula: C₆H₆N₂O₄
• Molecular Weight: 170.125
• Hs Code.: 2933399090
• Mol file: 75710-99-5.mol

Synonyms:3-Methoxy-5-nitropyridin-2(1H)-one;

Chemical Property of 3-Methoxy-5-nitropyridin-2-ol

Chemical Property:

• Vapor Pressure: 6.03E-05mmHg at 25°C
• Refractive Index: 1.561
• Boiling Point: 345.7 °C at 760 mmHg
• PKA: 8.53±0.10(Predicted)
• Flash Point: 162.9 °C
• PSA: 88.17000
• Density: 1.42 g/cm³
• LogP: 1.22720
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

3-Methoxy-5-nitro-pyridin-2-ol(~90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxy-5-nitro-pyridin-2-ol

Technology Process of 3-Methoxy-5-nitropyridin-2-ol

There total 5 articles about 3-Methoxy-5-nitropyridin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-methoxy-2-hydroxypyridine (20928-63-6,95907-05-4) → 3-methoxy-5-nitropyridin-2-ol (75710-99-5)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 40 ℃; for 3h;

Reference yield: 37.0%

3-methoxy-1H-pyridin-2-one (20928-63-6) → 3-methoxy-5-nitropyridin-2-ol (75710-99-5)

Guidance literature:

With sulfuric acid; nitric acid; at 45 ℃; for 1h;

DOI:10.1016/j.tet.2008.11.064

Reference yield:

dihydroxypyridine (16867-04-2) + dimethyl sulfate (77-78-1) → 3-methoxy-5-nitropyridin-2-ol (75710-99-5)

Guidance literature:

dihydroxypyridine; dimethyl sulfate; With sodium hydroxide; In water; at 5 - 20 ℃; for 20h;

With sulfuric acid; nitric acid; In water; at 5 - 15 ℃; for 0.5h;

upstream raw materials:

dihydroxypyridine

dimethyl sulfate

3-methoxy-1H-pyridin-2-one

3-methoxy-2-hydroxypyridine

Downstream raw materials:

2-chloro-3-methoxy-5-nitropyridine

phenyl 5-methoxy-6-(pyrrolidin-1-yl)pyridin-3-ylcarbamate

1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(5-methoxy-6-(pyrrolidin-1-yl)pyridin-3-yl)urea

C₁₆H₂₂N₂O₄Si