methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

Base Information

Chemical Name:methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate
CAS No.:1354826-26-8
Molecular Formula:C₃₉H₃₆F₃N₃O₆S₂
Molecular Weight:763.859
Hs Code.:

Synonyms:methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

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Chemical Property of methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

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Technology Process of methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

There total 12 articles about methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354652-78-0
methyl 3-(3-(chlorocarbonyl)benzylthio)propanoate

: 1354826-25-7
(2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

: 1354826-26-8
methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

Guidance literature:: With pyridine; In tetrahydrofuran; at 10 ℃; for 3h;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1354826-26-8
methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

2.2: 4.5 h / -80 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

3.2: 1 h / -80 - -20 °C

4.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

5.1: pyridine / tetrahydrofuran / 3 h / 10 °C

With pyridine; n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 26908-35-0
5-chloro-2-nitrobenzaldehyde ethylene acetal

: 1354826-26-8
methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

3.2: 4.5 h / -80 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

4.2: 1 h / -80 - -20 °C

5.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

6.1: pyridine / tetrahydrofuran / 3 h / 10 °C

With pyridine; hydrogenchloride; n-butyllithium; oxalyl dichloride; water; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;