(2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Chemical Name:(2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
CAS No.:1312473-54-3
Molecular Formula:C₁₈H₂₁FN₂O₆S
Molecular Weight:412.439
Hs Code.:

Synonyms:(2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Chemical Property of (2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Technology Process of (2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

There total 11 articles about (2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1312478-94-6
(2R)-4-{4-[2-fluoro-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2-oxopyridin-1(2H)-yl}-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1312473-54-3
(2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 20 - 25 ℃; for 0.166667h;

Reference yield:

: 121219-03-2
4-bromo-3-fluorophenol

: 1312473-54-3
(2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 2 h

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.08 h / -78 °C / Inert atmosphere

2.2: -78 - 25 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 42 h / 100 °C

4.1: potassium carbonate / Pd EnCat_.(TM). / 1,4-dioxane; water / 66 h / 100 °C

5.1: hydrogenchloride / 1,4-dioxane; water / 0.17 h / 20 - 25 °C

With hydrogenchloride; potassium acetate; pyridinium p-toluenesulfonate; potassium carbonate; lithium diisopropyl amide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 22282-70-8
2-fluoro-4-iodopyridine

: 1312473-54-3
(2R)-4-{4-[2-fluoro-4-hydroxy-3-methylphenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / water / Reflux

2.1: caesium carbonate / tetrahydrofuran / 20 - 60 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 - 25 °C

3.2: pH 2

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 - 25 °C

5.1: potassium carbonate / Pd EnCat_.(TM). / 1,4-dioxane; water / 66 h / 100 °C

6.1: hydrogenchloride / 1,4-dioxane; water / 0.17 h / 20 - 25 °C

With hydrogenchloride; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; Pd EnCat; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;