Methyl 1-(Mercaptomethyl)cyclopropaneacetate

Base Information

• Chemical Name: Methyl 1-(Mercaptomethyl)cyclopropaneacetate
• CAS No.: 152922-73-1
• Molecular Formula: C7H12O2S
• Molecular Weight: 160.237
• Hs Code.: 2930909090
• Mol file: 152922-73-1.mol

Synonyms:1-(Mercaptomethyl)cyclopropaneaceticacid methyl ester;Methyl2-[1-(mercaptomethyl)cyclopropyl]acetate;

Chemical Property of Methyl 1-(Mercaptomethyl)cyclopropaneacetate

Chemical Property:

• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.495
• Boiling Point: 208.899 °C at 760 mmHg
• PKA: 10.41±0.10(Predicted)
• Flash Point: 92.703 °C
• PSA: 65.10000
• Density: 1.11 g/cm³
• LogP: 1.25950

Purity/Quality:

99% ^*data from raw suppliers

Methyl1-(Mercaptomethyl)cyclopropaneacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-(Mercaptomethyl)cyclopropaneacetate

There total 5 articles about Methyl 1-(Mercaptomethyl)cyclopropaneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diiodomethane (75-11-6) + C6H10O2S → 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester (152922-73-1)

Guidance literature:

With diethylzinc; In hexane; dichloromethane; at 0 ℃; for 31.5h;

Reference yield: 73.0%

methanol (67-56-1) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester (152922-73-1)

Guidance literature:

With sulfuric acid; for 5h; Reflux;

DOI:10.1002/bkcs.12205

Reference yield:

methanol (67-56-1) + 1-(Acetylthiomethyl)cyclopropaneacetonitrile (152922-72-0) → 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester (152922-73-1)

Guidance literature:

With hydrogenchloride; In water; at 70 - 75 ℃; for 20h;

upstream raw materials:

1-(Acetylthiomethyl)cyclopropaneacetonitrile

water

methanol

1-(sulfanylmethyl)cyclopropaneacetic acid

Downstream raw materials:

1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate

1-(sulfanylmethyl)cyclopropaneacetic acid

1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester

montelukast

Refernces

• 1、 -. "Preparation method of 1-mercaptomethylcyclopropylacetic acid". Paragraph 0019; 0028. . Retrieved 2019/10/04.
• 2、 -. "IMPROVED PROCESS FOR PURE MONTELUKAST SODIUM THROUGH PURE INTERMEDIATES AS WELL AS NOVEL AMINE SALTS". Page/Page column 33. . Retrieved 2008/12/05.