(R)-Carnitine hydrochloride

Base Information

• Chemical Name: (R)-Carnitine hydrochloride
• CAS No.: 6645-46-1
• Molecular Formula: C7H16ClNO3
• Molecular Weight: 197.662
• Hs Code.: 29239000
• Mol file: 6645-46-1.mol

Synonyms:L-Carnitine hydrochloride;(R)-Carnitine hydrochloride;L-Carnitine (hydrochloride);(R)-Carnitine (hydrochloride);SCHEMBL932466;JXXCENBLGFBQJM-FYZOBXCZSA-N

Chemical Property of (R)-Carnitine hydrochloride

Chemical Property:

• Appearance/Colour: white to slightly beige crystalline powder
• Melting Point: 142 °C
• PSA: 60.36000
• LogP: -1.00450
• Storage Temp.: −20°C
• Solubility.: Water
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 197.0818711
• Heavy Atom Count: 12
• Complexity: 134

Purity/Quality:

98%-102%, ^*data from raw suppliers

(R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminiumChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+](C)(C)CC(CC(=O)[O-])O.Cl
• Isomeric SMILES: C[N+](C)(C)C[C@@H](CC(=O)[O-])O.Cl
• Uses: L-Carnitine hydrochloride has been used to study ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5. It has also been used to allow the entry of palmitic acid into the mitochondria.

Technology Process of (R)-Carnitine hydrochloride

There total 16 articles about (R)-Carnitine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R)-(-)-3-cyano-2-hydroxypropyltrimethylammonium chloride (2788-28-5,1116-95-6) → L-carnitine chloride (6645-46-1)

Guidance literature:

With hydrogenchloride; water;

DOI:10.1016/j.cclet.2011.01.007

Reference yield: 90.0%

(+)-(3R,2'S)-ethyl 3-<(2-methoxy-2-phenylacetyl)oxy>-4-(triethylammonio)butanoate iodide (107799-28-0) → L-carnitine chloride (6645-46-1)

Guidance literature:

With hydrogenchloride; 1.) 60 deg C, 2 h, 2.) RT, 16 h;

DOI:10.1021/jo00387a041

Reference yield: 78.5%

→ (R)-carnitine hydrochloride (56-99-5,461-05-2,6645-46-1,10017-44-4)

Guidance literature:

upstream raw materials:

(2R)-(-)-3-cyano-2-hydroxypropyltrimethylammonium chloride

(+)-(3R,2'S)-ethyl 3-<(2-methoxy-2-phenylacetyl)oxy>-4-(triethylammonio)butanoate iodide

ethyl (L)-4-chloro-3-hydroxybutyrate

dimethyl amine

Downstream raw materials:

O-acetyl-L-carnitine hydrochloride

acetyl-D,L-carnitine*HCl

Acetyl-L-carnitine

o-palmitoyl-L-carnitine hydrochloride

Refernces

• 1、 Li, Xu Qin,Yang, Yun Xu,Wang, Wei Li,Hu, Bin,Xue, Hui Min,Zhang, Tian Yi,Zhang, Xue Tao. "Asymmetric synthesis of l-carnitine from (R)-3-chloro-1,2-propanediol". body text. p. 765 - 767. Retrieved 2012/01/03.
• 2、 -. "PROCESS FOR L-CARNITINE AND ACETYL L-CARNITINE HYDROCHLORIDE". Page/Page column 9-10. . Retrieved 2010/11/29.