(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Chemical Name:(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester
CAS No.:148432-31-9
Molecular Formula:C₄₂H₆₆N₂O₆
Molecular Weight:694.996
Hs Code.:

Synonyms:(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Chemical Property of (R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Technology Process of (R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

There total 4 articles about (R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 3587-60-8
Benzyloxymethyl chloride

: 148432-23-9
(R)-2-[(E)-(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-hydroxy-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

: 148432-31-9
(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h; Heating;

Reference yield:

: 118535-62-9
(S)-(-)-1-amino-2-(1'-methoxy-1'-ethylpropyl)pyrrolidine

: 148432-31-9
(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / cyclohexane

2: 1) LDA, LiBr / 1) THF, hexane, -78 deg C, 1-2 h, 2) THF, a) 1-2 h, -90 deg C, b) -78 deg C, 1 h

3: 91 percent / nBu₄NI, iPr₂NEt / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In dichloromethane; cyclohexane;

Reference yield:

: 145656-72-0
2,6-di-tert-butyl-4-methoxyphenyl pyruvate

: 148432-31-9
(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / cyclohexane

2: 1) LDA, LiBr / 1) THF, hexane, -78 deg C, 1-2 h, 2) THF, a) 1-2 h, -90 deg C, b) -78 deg C, 1 h

3: 91 percent / nBu₄NI, iPr₂NEt / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In dichloromethane; cyclohexane;