tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane

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Chemical Name:tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane
CAS No.:240815-93-4
Molecular Formula:C₃₆H₄₆I₂O₂Si
Molecular Weight:792.655
Hs Code.:

Synonyms:tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane

There total 10 articles about tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 240815-92-3
(4E,8E)-(S)-7-(tert-Butyl-dimethyl-silanyloxy)-9-iodo-8-methyl-4-trityloxymethyl-nona-4,8-dien-1-ol

: 240815-93-4
tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; acetonitrile; at 0 ℃; for 0.75h;
DOI:10.1016/S0968-0896(98)00153-9

Reference yield:

: 76-83-5
trityl chloride

: 240815-93-4
tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 4-DMAP / dimethylformamide / 21 h / 80 °C

2: 95 percent / 9-BBN / tetrahydrofuran / 9 h / 0 °C

3: 97 percent / I₂, PPh₃, imidazole / diethyl ether; acetonitrile / 0.75 h / 0 °C

With 1H-imidazole; dmap; 9-borabicyclo[3.3.1]nonane dimer; iodine; triphenylphosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(98)00153-9

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 240815-93-4
tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / imidazole / dimethylformamide / 7 h / 0 - 25 °C

2: 89 percent / OsO₄, NMO / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 13 h / 25 °C

3: 92 percent / NaIO₄ / methanol; H₂O / 0.5 h / 25 °C

4: 98 percent / benzene / 1.5 h / Heating

5: 100 percent / DIBAL / tetrahydrofuran; CH₂Cl₂ / 1.33 h / -78 °C

6: 95 percent / 4-DMAP / dimethylformamide / 21 h / 80 °C

7: 95 percent / 9-BBN / tetrahydrofuran / 9 h / 0 °C

8: 97 percent / I₂, PPh₃, imidazole / diethyl ether; acetonitrile / 0.75 h / 0 °C

With 1H-imidazole; dmap; sodium periodate; osmium(VIII) oxide; 9-borabicyclo[3.3.1]nonane dimer; N-methyl-2-indolinone; iodine; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1016/S0968-0896(98)00153-9