(12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

Base Information

Chemical Name:(12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one
CAS No.:240815-96-7
Molecular Formula:C₆₀H₉₇IO₆Si₃
Molecular Weight:1125.59
Hs Code.:

(12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

Synonyms:(12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

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Chemical Property of (12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

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Technology Process of (12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

There total 21 articles about (12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 187527-25-9
(-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one

: 226940-68-7
(6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-11-iodo-2,10-dimethyl-6-trityloxymethyl-undeca-6,10-dienal

: 240815-96-7
(12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

Guidance literature:: (-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 1.5h;

(6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-11-iodo-2,10-dimethyl-6-trityloxymethyl-undeca-6,10-dienal; In tetrahydrofuran; hexane; at -78 ℃; for 0.0333333h;
DOI:10.1002/1521-3765(20000804)6:15<2783::AID-CHEM2783>3.0.CO;2-B

Reference yield:

: 226940-40-5
(S)-7-(tert-butyl-dimethyl-silanyloxy)-6-methyl-2-(triphenylphosphanylidene)-heptanoic acid methyl ester

: 240815-96-7
(12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / benzene / 18 h / Heating

2.1: 71 percent / DIBAL / tetrahydrofuran / 3 h / -78 °C

3.1: 94 percent / DMAP / dimethylformamide / 24 h / 80 °C

4.1: 67 percent / HF*py; pyridine / tetrahydrofuran / 4 h / 25 °C

5.1: 98 percent / SO₃*py; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 1 h / 0 °C

6.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 - -40 °C

6.2: 74 percent / tetrahydrofuran; hexane / 0.03 h / -78 °C

With pyridine; dmap; pyridine-SO₃ complex; diisobutylaluminium hydride; pyridine hydrogenfluoride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene; 1.1: Condensation / 2.1: Reduction / 3.1: Etherification / 4.1: Silyl ether cleavage / 5.1: Oxidation / 6.1: Metallation / 6.2: Addition;
DOI:10.1002/1521-3765(20000804)6:15<2783::AID-CHEM2783>3.0.CO;2-B

Reference yield:

: 226940-65-4
(2E,6E)-(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentyl]-7-iodo-6-methyl-hepta-2,6-dien-1-ol

: 240815-96-7
(12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / DMAP / dimethylformamide / 24 h / 80 °C

2.1: 67 percent / HF*py; pyridine / tetrahydrofuran / 4 h / 25 °C

3.1: 98 percent / SO₃*py; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 1 h / 0 °C

4.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 - -40 °C

4.2: 74 percent / tetrahydrofuran; hexane / 0.03 h / -78 °C

With pyridine; dmap; pyridine-SO₃ complex; pyridine hydrogenfluoride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: Silyl ether cleavage / 3.1: Oxidation / 4.1: Metallation / 4.2: Addition;
DOI:10.1002/1521-3765(20000804)6:15<2783::AID-CHEM2783>3.0.CO;2-B