1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene

Base Information

• Chemical Name: 1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene
• CAS No.: 1420041-79-7
• Molecular Formula: C₉H₇FI₂
• Molecular Weight: 387.962
• Mol file: 1420041-79-7.mol

Synonyms:1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene

Chemical Property of 1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene

There total 2 articles about 1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(4-methylphenyl)prop-2-ynoic acid (2227-58-9) → 1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene (1420041-79-7)

Guidance literature:

With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; silver(I) acetate; pyridine hydrogenfluoride; In acetonitrile; at 40 ℃; for 16h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.9b00597

Reference yield:

1-(iodoethynyl)-4-methylbenzene (33675-56-8) → 1-((Z)-1-fluoro-2-iodovinyl)-4-methylbenzene (1420041-77-5) + 1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene (1420041-79-7)

Guidance literature:

With water; silver fluoride; In acetonitrile; at 80 ℃; for 8h; Overall yield = 74 %; stereoselective reaction; Schlenk technique;

DOI:10.1002/adsc.201200250

Reference yield: 94.0%

1-(1-fluoro-2,2-diiodovinyl)-4-methylbenzene (1420041-79-7) + phenylboronic acid (98-80-6) → (2-fluoro-2-(p-tolyl)ethene-1,1-diyl)dibenzene

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triphenylphosphine; In ethanol; water; toluene; at 80 ℃; for 20h; regioselective reaction;

DOI:10.1021/acs.orglett.9b00597

upstream raw materials:

1-(iodoethynyl)-4-methylbenzene

3-(4-methylphenyl)prop-2-ynoic acid