33675-56-8Relevant academic research and scientific papers
Copper-Catalyzed Hydrogen/Iodine Exchange in Terminal and 1-Iodoalkynes
Chung, Ryan,Vo, Anh,Hein, Jason E.
, p. 2505 - 2510 (2017)
Detailed kinetic profiles of the copper-catalyzed exchange between the acetylenic proton and iodide of terminal and 1-iodophenylacetylenes are reported. The electronic nature of the alkynes does not influence the equilibrium of the exchange (Keq/sub
Synthesis method of 1-iodo-alkyne compound
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Paragraph 0040-0043, (2021/01/24)
The invention discloses a synthetic method of a 1-iodo-alkyne compound. The preparation method comprises the following steps: in an aerobic environment, mixing terminal alkyne, soluble inorganic iodized salt, sodium phenylsulfinate or a derivative thereof
Efficient synthesis of 1-iodoalkynes: Via Al2O3 mediated reaction of terminal alkynes and N -iodosuccinimide
Yao, Ming,Zhang, Jingjing,Yang, Sen,Xiong, Hangxing,Li, Li,Liu,Shi, Hong
, p. 3946 - 3950 (2020/02/04)
Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.
Au(I)-Catalyzed Hydration of 1-Iodoalkynes Leading to α-Iodoketones
Cazin, Catherine S. J.,Gómez-Herrera, Alberto,Hashim, Ishfaq Ibni,Nahra, Fady,Porré, Marre
supporting information, p. 6790 - 6794 (2020/11/23)
A catalytic protocol for the Au(I)-catalyzed hydration of 1-iodoalkynes is disclosed. The use of Au(I)–NHC catalyst enabled the straightforward synthesis of a variety of α-iodomethyl ketones in good to excellent yields. The utility of this simple method is further highlighted by showcasing iodination/hydration and hydration/oxidation sequential protocols leading to the construction of molecular complexity.
Reaction of 1-Iodoalkynes with Tin Metal: A New Approach to the Sn–C sp Bond Formation
Chikava, A. R.,Konshin, V. V.,Levashov, A. S.
, p. 610 - 613 (2020/07/02)
Abstract: Tin iodoalkynylides were synthesized by the reaction of 1-iodoalkynes with tin metal. The scope of the reaction and the composition of the resulting mixtures were studied. The formation of tin iodoalkynylides was confirmed by counter synthesis v
Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N -Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes
Liu, Liu E.,Xiong, Hangxing,Yang, Sen,Yao, Ming,Zhang, Jingjing
supporting information, p. 1102 - 1106 (2020/07/04)
An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired products in good to excellent yields (up to 99percent).
Iodination of terminal alkynes using KI/CuSO4 – A facile method with potential for radio-iodination
Ferris, Trevor,Carroll, Laurence,Mease, Ronnie C.,Spivey, Alan C.,Aboagye, Eric O.
supporting information, p. 936 - 939 (2019/03/04)
Herein, we report an efficient new method for the iodination of terminal alkynes using stoichiometric KI and CuSO4 in a mix of acetonitrile and acetate buffer that holds promise for further development into a method for radio-iodination.
Synthesis of 5H-Selenopheno[3,2-c]isochromen-5-ones Promoted by Dialkyl Diselenides and Oxone
Goulart, Helen A.,Neto, José S. S.,Barcellos, Angelita M.,Barcellos, Thiago,Silva, Márcio S.,Alves, Diego,Jacob, Raquel G.,Lenard?o, Eder J.,Perin, Gelson
supporting information, p. 3403 - 3411 (2019/05/28)
We describe here for the first time the synthesis of isochromenones fused to selenophenes. 5H-Selenopheno[3,2-c]isochromen-5-ones were obtained through a double intramolecular cyclization of methyl 2-(organyl-1,3-diynyl)benzoate promoted by electrophilic species of selenium generated in situ by the reaction of dialkyl diselenides with Oxone, using ethanol as solvent. The reactions were conducted satisfactorily under mild conditions, using a range of 1,3-diynes and dialkyl diselenides as substrates. A total of sixteen unprecedent 5H-selenopheno[3,2-c]isochromen-5-ones were selectively obtained in moderate to good yields (40–86%) under reflux in an open flask and in short reaction times (1.0–2.5 h). (Figure presented.).
Synthesis of fluoroalkylated alkynes: Via visible-light photocatalysis
Iqbal, Naila,Iqbal, Naeem,Han, Sung Su,Cho, Eun Jin
supporting information, p. 1758 - 1762 (2019/02/20)
Fluoroalkylated alkynes, which are versatile building blocks for the synthesis of various biologically active organofluorine compounds, were synthesized from easily available alkynyl halides and fluoroalkyl halides by visible-light photocatalysis. Addition of fluoroalkyl radicals to alkynes and subsequent dehalogenation selectively yielded fluoroalkylated alkynes.
Chloramine Salt Mediated Oxidative Halogenation of Terminal Alkynes with KI or NaBr: Practical Synthesis of 1-Bromoalkynes and 1-Iodoalkynes
Liu, Xiaozu,Chen, Guojun,Li, Chenglong,Liu, Peijun
, p. 2051 - 2055 (2018/09/18)
A direct oxidative halogenation of terminal alkynes has been realized using chloramine-B as the oxidant and KI or NaBr as the halogen source. This reaction enables a general and practical access to synthetically valuable 1-bromoalkynes and 1-iodoalkynes i
