2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester

Base Information

• Chemical Name: 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester
• CAS No.: 337355-96-1
• Molecular Formula: C₂₄H₂₅NO₅
• Molecular Weight: 407.466

Synonyms:2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester

Chemical Property of 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester

Chemical Property:

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Technology Process of 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester

There total 1 articles about 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + 3-(4-benzyloxy-phenyl)-isoxazol-5-carbaldehyde (337355-81-4) → 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester (337355-96-1)

Guidance literature:

acrylic acid n-butyl ester; With 1,4-diaza-bicyclo[2.2.2]octane; at 20 ℃; for 0.333333h;

3-(4-benzyloxy-phenyl)-isoxazol-5-carbaldehyde; at 20 ℃; for 0.333333h;

DOI:10.1055/s-2001-10815

Reference yield: 57.0%

1-methyl-piperazine (109-01-3) + 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester (337355-96-1) → 3-[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-3-hydroxy-2-(4-methyl-piperazin-1-ylmethyl)-propionic acid butyl ester

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2004.02.023

Reference yield:

acetyl chloride (75-36-5) + 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid butyl ester (337355-96-1) → 2-{acetoxy-[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-methyl}-acrylic acid butyl ester (713137-91-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2004.02.023

upstream raw materials:

acrylic acid n-butyl ester

3-(4-benzyloxy-phenyl)-isoxazol-5-carbaldehyde

Downstream raw materials:

2-{acetoxy-[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-methyl}-acrylic acid butyl ester

2-[3-(4-benzyloxy-phenyl)-isoxazol-5-ylmethyl]-acrylic acid butyl ester

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