(S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate

Base Information

• Chemical Name: (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate
• CAS No.: 1278521-19-9
• Molecular Formula: C₁₀H₈Cl₄O₂
• Molecular Weight: 301.984
• Mol file: 1278521-19-9.mol

Synonyms:(S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate

Chemical Property of (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate

There total 2 articles about (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(R)-2-chloro-1-(2',4'-dichlorophenyl)-1-ethanol (114446-57-0) + chloroacetic acid (79-11-8) → (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate (1278521-19-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1021/jo102459w

Reference yield:

2,2',4'-trichloroacetophenone (4252-78-2) → (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate (1278521-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: alcohol dehydrogenase PR₂; isopropyl alcohol; NADPH; magnesium chloride / 24 h / 30 °C / pH 7.5 / TRIS-HCl buffer; Enzymatic reaction

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C

With alcohol dehydrogenase PR₂; triphenylphosphine; isopropyl alcohol; NADPH; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; 2: Mitsunobu reaction;

DOI:10.1021/jo102459w

Reference yield: 86.0%

(S)-2-chloro-1-(2,4-dichlorophenyl)ethyl chloroacetate (1278521-19-9) → (S)-2-(2,4-dichlorophenyl)oxirane (141394-11-8)

Guidance literature:

With water; potassium carbonate; In methanol; for 3h; Reflux;

DOI:10.1021/jo102459w

upstream raw materials:

(R)-2-chloro-1-(2',4'-dichlorophenyl)-1-ethanol

chloroacetic acid

2,2',4'-trichloroacetophenone

Downstream raw materials:

(S)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

(S)-1-(2-((4-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

(+)-Miconazole

(S)-2-(2,4-dichlorophenyl)oxirane

Refernces