3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

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Chemical Name:3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid
CAS No.:1621706-08-8
Molecular Formula:C₃₄H₂₈F₂N₄O₆S
Molecular Weight:658.682
Hs Code.:

Synonyms:3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

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Chemical Property of 3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

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Technology Process of 3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

There total 6 articles about 3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621706-07-7
ethyl 3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoate

: 1621706-08-8
3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 148493-37-2
2,6-dichloro-3-iodo-pyridine

: 1621706-08-8
3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

3: caesium carbonate; XPhos / water; 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

4: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 9 h / 90 °C / Inert atmosphere

5: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); water; hydrogen; potassium carbonate; caesium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;

Reference yield:

: 1621706-02-2
(E)-ethyl 3-(2, 6-dichloropyridin-3-yl)acrylate

: 1621706-08-8
3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

2: caesium carbonate; XPhos / water; 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

3: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 9 h / 90 °C / Inert atmosphere

4: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); water; hydrogen; caesium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;