5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621704-76-4
Molecular Formula:C₃₄H₂₆F₂N₄O₅S
Molecular Weight:640.667
Hs Code.:

5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 7 articles about 5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621706-08-8
3-(2-(4-fluoro-1H-indol-2-yl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyridin-3-yl)propanoic acid

: 1621704-76-4
5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1621706-02-2
(E)-ethyl 3-(2, 6-dichloropyridin-3-yl)acrylate

: 1621704-76-4
5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

2: caesium carbonate; XPhos / water; 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

3: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 9 h / 90 °C / Inert atmosphere

4: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 20 °C

5: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 864830-51-3
(E)-ethyl 3-(2,6-dichloropyridin-3-yl)propanoate

: 1621704-76-4
5-(12-fluoro-7-oxo-6,7-dihydro-5H-pyrido[2’,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; XPhos / water; 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

2: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 9 h / 90 °C / Inert atmosphere

3: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 20 °C

4: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With lithium hydroxide monohydrate; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); water; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;