226917-14-2

Basic information

• Product Name: [[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol
• Synonyms: [[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol
• CAS NO: 226917-14-2
• Molecular Weight: 650.488
• Mol File: 226917-14-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol(CAS DataBase Reference)
• NIST Chemistry Reference: [[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol(226917-14-2)
• EPA Substance Registry System: [[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol(226917-14-2)

Safety Data

• Hazardous Substances Data: 226917-14-2(Hazardous Substances Data)

Upstream product

• 315682-14-5 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one 
• 199997-50-7 4-(3,4-dichloro-phenyl)-5-hydroxymethyl-dihydro-furan-2-one 
• 184968-61-4 3-(3,4-di-chlorophenyl)-4-pentenoic acid 
• 315682-11-2 3-(3,4-dichloro-phenyl)-2-propene-1-ol acetate 
• 82475-75-0 methyl 3-(3,4-dichlorophenyl)-2-propenoate 
• 148775-22-8 3-(3,4-dichlorophenyl)-prop-2-en-1-ol 
• 7312-27-8 3,4-Dichlorocinnamic acid 

Downstream Products

• 184968-72-7 1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone 

Relevant articles and documents

The design and synthesis of novel NK1/NK2 dual antagonists

Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class. The addition of the amino or the oxime functional group results in the reversal of the stereochemical preference of the NK2 receptor. (C) 2000 Elsevier Science Ltd.