bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

Base Information

Chemical Name:bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate
CAS No.:1337533-22-8
Molecular Formula:C₄₃H₄₄F₂N₄O₈
Molecular Weight:782.841
Hs Code.:

bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

Synonyms:bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

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Chemical Property of bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

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Technology Process of bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

There total 3 articles about bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.1%

: potassium benzyl N-[2-(trifluoroboranuidyl)ethyl]carbamate

: 1337533-20-6
bis(1,1-dimethylethyl) (3-(1-[(2,5-difluorophenyI)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-iodofuro[3,2-c]pyridin-4-yI)imidodicarbonate

: 1337533-22-8
bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

Guidance literature:: With caesium carbonate; palladium diacetate; ruphos; In water; toluene; at 95 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1337532-96-3
3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-iodofuro[3,2-c]pyridin-4-amine

: 1337533-22-8
bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere

2: caesium carbonate / palladium diacetate; ruphos / toluene; water / 16 h / 95 °C / Inert atmosphere

With caesium carbonate; triethylamine; dmap; palladium diacetate; ruphos; In dichloromethane; water; toluene;

Reference yield:

: 1337531-46-0
3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}furo[3,2-c]pyridin-4-amine

: 1337533-22-8
bis(1,1-dimethylethyl) (3-(-1[(2,5difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-[2-(([(phenylmethyl)oxy]carbonyl)amino)ethyl]furo[3,2-c]pyridin-4-yl)imidodicarbonate

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 18 h / -40 - 20 °C

2: triethylamine / dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere

3: caesium carbonate / palladium diacetate; ruphos / toluene; water / 16 h / 95 °C / Inert atmosphere

With N-iodo-succinimide; caesium carbonate; triethylamine; dmap; palladium diacetate; ruphos; In dichloromethane; water; N,N-dimethyl-formamide; toluene;