17α-hydroxy-4-estren-3-one 17-benzoate

Base Information

• Chemical Name: 17α-hydroxy-4-estren-3-one 17-benzoate
• CAS No.: 1312782-62-9
• Molecular Formula: C₂₅H₃₀O₃
• Molecular Weight: 378.511
• Mol file: 1312782-62-9.mol

Synonyms:17α-hydroxy-4-estren-3-one 17-benzoate

Chemical Property of 17α-hydroxy-4-estren-3-one 17-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 17α-hydroxy-4-estren-3-one 17-benzoate

There total 1 articles about 17α-hydroxy-4-estren-3-one 17-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

19-nortestosterone (434-22-0) + benzoic acid (65-85-0,8013-63-6) → 17α-hydroxy-4-estren-3-one 17-benzoate (1312782-62-9)

Guidance literature:

With 2-(diphenylphosphino)pyridine; di-isopropyl azodicarboxylate; In toluene; at 80 ℃; for 18h; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.steroids.2011.03.004

Reference yield: 68.2%

17α-hydroxy-4-estren-3-one 17-benzoate (1312782-62-9) → 5α‐estrane‐3β,17α‐diol (93602-55-2)

Guidance literature:

17α-hydroxy-4-estren-3-one 17-benzoate; With ammonia; lithium; In 1,4-dioxane; diethyl ether; for 0.5h; Inert atmosphere;

With ethanol; In 1,4-dioxane; diethyl ether; for 0.333333h; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.steroids.2011.03.004

Reference yield:

17α-hydroxy-4-estren-3-one 17-benzoate (1312782-62-9) → 17α-benzoylestradiol

Guidance literature:

With lithium bromide; copper(ll) bromide; In ethyl acetate; at 90 ℃; for 4.5h;

upstream raw materials:

19-nortestosterone

benzoic acid

Downstream raw materials:

5α‐estrane‐3β,17α‐diol

Refernces

• 1、 Schneider, Gyula,Kiss, Anita,Mernyák, Erzsébet,Benke, Zsanett,W?lfling, János,Frank, éva,Bózsity, Noémi,Gyovai, András,Minorics, Renáta,Zupkó, István. "Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities". . p. 113 - 120. Retrieved 2016.