5α-Estrane-3β,17α-diol

Base Information

• Chemical Name: 5α-Estrane-3β,17α-diol
• CAS No.: 93602-55-2
• Molecular Formula: C₁₈H₃₀O₂
• Molecular Weight: 278.435
• Mol file: 93602-55-2.mol

Synonyms:5α-Estrane-3β,17α-diol;5a-Estrane-3,17a-diol

Chemical Property of 5α-Estrane-3β,17α-diol

Chemical Property:

• Melting Point: 199-201°C
• PSA: 40.46000
• LogP: 3.36080
• Storage Temp.: Controlled Substance, -20?C Freezer

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of 17β-Nandrolone (N315000).

Technology Process of 5α-Estrane-3β,17α-diol

There total 14 articles about 5α-Estrane-3β,17α-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.2%

17α-hydroxy-4-estren-3-one 17-benzoate (1312782-62-9) → 5α‐estrane‐3β,17α‐diol (93602-55-2)

Guidance literature:

17α-hydroxy-4-estren-3-one 17-benzoate; With ammonia; lithium; In 1,4-dioxane; diethyl ether; for 0.5h; Inert atmosphere;

With ethanol; In 1,4-dioxane; diethyl ether; for 0.333333h; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.steroids.2011.03.004

Reference yield:

→ 5α,10α-Oestran-3β,17β-diol (517-01-1,1434-84-0,1816-75-7,10002-95-6,10002-97-8,37795-40-7,65556-20-9,67392-82-9,75044-89-2,93602-55-2,94424-31-4,94424-32-5,95340-51-5,95340-52-6,98920-62-8,138812-56-3,151122-91-7)

Guidance literature:

Oestr-5(10)-en-3β,17β-diol 6b, Ru-oxid, Hydrierung;

Reference yield:

→ 5α,10α-Oestrandiol-(3α,17β) (517-01-1,1434-84-0,1816-75-7,10002-95-6,10002-97-8,37795-40-7,65556-20-9,67392-82-9,75044-89-2,93602-55-2,94424-31-4,94424-32-5,95340-51-5,95340-52-6,98920-62-8,138812-56-3,151122-91-7)

Guidance literature:

Oestratrien-(A)-diol, Rutheniumdioxyd, A., wenig wss. NaOH, 65grad, 100 at, Hydrieren, neben 5α,10α-Oestradiol-(3β,17β);

DOI:10.1016/0040-4020(61)80027-6

upstream raw materials:

17α-hydroxy-4-estren-3-one 17-benzoate

19-nortestosterone

Refernces