Technology Process of N-(2-(2-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)ethoxy)ethyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
There total 14 articles about N-(2-(2-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)ethoxy)ethyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: boron tribromide / dichloromethane / -78 - 4 °C / Inert atmosphere
2: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C
3: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C
4: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 3 h / 20 °C
5: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C
6: ammonium chloride; iron / methanol / 5 h / 65 °C
With
hydrogenchloride; boron tribromide; iron; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C
2: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C
3: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 3 h / 20 °C
4: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C
5: ammonium chloride; iron / methanol / 5 h / 65 °C
With
hydrogenchloride; iron; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: formic acid; dihydrogen peroxide / 4 h / 20 - 40 °C
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C
2.2: 3 h / 25 °C
3.1: potassium hydroxide / water / 20 °C
4.1: hydrogenchloride; water / 1 h / Reflux
5.1: ammonia / water / 5 h / Heating
6.1: trichlorophosphate / 1 h / 110 °C / microwave irradiation
7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C
8.1: ammonium chloride; iron / methanol / 5 h / 65 °C
With
hydrogenchloride; n-butyllithium; formic acid; ammonia; water; dihydrogen peroxide; iron; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; hexanes; water; acetonitrile;
