3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

Base Information

Chemical Name:3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one
CAS No.:907187-03-5
Molecular Formula:C₁₉H₂₃NO₄
Molecular Weight:329.396
Hs Code.:

Synonyms:3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

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Chemical Property of 3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

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Technology Process of 3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

There total 6 articles about 3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 907187-56-8
methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate

: 907187-03-5
3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 - 90 ℃;
DOI:10.1021/jf3002069

Reference yield:

: 54621-18-0
8-amino-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid

: 907187-03-5
3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 7 h / 0 °C / Reflux

2: potassium carbonate / acetonitrile / 3 h / 20 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 90 °C

With hydrogenchloride; potassium tert-butylate; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; 3: Dieckmann reaction;
DOI:10.1021/jf3002069

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 907187-03-5
3-(2,5-dimethylphenyl)-9,12-dioxa-4-hydroxy-1-azadispiro[4.2.4.2]tetradec-3-en-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium cyanide / ethanol; water / 8 h / 55 - 60 °C

1.2: 0 °C

2.1: sodium hydroxide / 96 h / Inert atmosphere; Reflux

2.2: 0 °C / pH 6

3.1: hydrogenchloride / 7 h / 0 °C / Reflux

4.1: potassium carbonate / acetonitrile / 3 h / 20 °C

5.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 90 °C

With hydrogenchloride; potassium cyanide; potassium tert-butylate; potassium carbonate; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; 5.1: Dieckmann reaction;
DOI:10.1021/jf3002069