DL-Methionine methylsulfonium chloride

Base Information

• Chemical Name: DL-Methionine methylsulfonium chloride
• CAS No.: 3493-12-7
• Deprecated CAS: 41844-44-4,1086685-49-5,1086685-49-5
• Molecular Formula: C6H14 NO2 S^.Cl
• Molecular Weight: 199.702
• Hs Code.: 29309090
• European Community (EC) Number: 222-484-4
• UNII: 5Q59I6H55O
• DSSTox Substance ID: DTXSID6046713
• Wikipedia: S-Methylmethionine
• Wikidata: Q27262729
• ChEMBL ID: CHEMBL2107104
• Mol file: 3493-12-7.mol

Synonyms:DL-Met-S-methylsulfonium chloride;DL-methionine-S-methylsulfonium chloride;methionylmethylsulfonium chloride;MMSC

Chemical Property of DL-Methionine methylsulfonium chloride

Chemical Property:

• Melting Point: 139-140 °C (dec.)
• PSA: 88.62000
• LogP: -2.62940
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: H2O: soluble100mg/mL, clear, colorless
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 199.0433776
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

99% ^*data from raw suppliers

DL-Methionine methylsulfonium chloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[S+](C)CCC(C(=O)O)N.[Cl-]
• Uses: DL-Methionine Methylsulfonium Chloride is a compound comprised of γ-glutamyl peptide and amino acid that have a sucrose-like taste. Vitamin U (DL-methionine methylsulfonium chloride) is a natural methionine-derivative, found as an active component in the methionine cycle of plants where it serves as a substrate for methyl transferases (Augspurger et al., 2005). Historically this compound has been utilized as either a cure or preventative against gastric and duodenal ulcers (Nakamura et al., 1981).

Technology Process of DL-Methionine methylsulfonium chloride

There total 2 articles about DL-Methionine methylsulfonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

L-methionine (63-68-3,26062-47-5,58576-49-1) + methyl iodide (74-88-4) → L-S-methylmethionine sulfonium chloride (1115-84-0,3493-12-7,41844-44-4,71267-08-8)

Guidance literature:

L-methionine; methyl iodide; In methanol; water; at 20 ℃; for 48h; Darkness;

With Dowex Cl^- form; In water;

DOI:10.1021/jm300571h

Reference yield:

→ DL-methionine-S-methylsulfonium chloride (3493-12-7)

Guidance literature:

Methionin-methyl-sulfonium-fluorborat (VII), KCl, W.;

Reference yield: 96.0%

DL-methionine-S-methylsulfonium chloride (3493-12-7) + glycine (56-40-6,18875-39-3,25718-94-9) + zinc(II) oxide → (diaquachloro-S-methylmethioniato)(glycinato)zinc

Guidance literature:

In water; reaction of ZnO with ligands in H2O (equimolar amounts); elem. anal.;

upstream raw materials:

L-methionine

methyl iodide

Downstream raw materials:

methyl bromide

methylene chloride

methyl iodide

dimethylsulfide

Refernces