2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Base Information

• Chemical Name: 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine
• CAS No.: 137023-12-2
• Molecular Formula: C₂₇H₃₆N₂O₇
• Molecular Weight: 500.592
• Mol file: 137023-12-2.mol

Synonyms:2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Chemical Property of 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

There total 6 articles about 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (137023-11-1) → 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (137023-12-2)

Guidance literature:

With ammonia; sodium; In tetrahydrofuran; ethanol; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (137023-08-6) → 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (137023-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 80.2 percent / formic acid / 10percentPd/C / methanol / 0.75 h / Ambient temperature

2: 90.1 percent / NaI / tetrahydrofuran / 2 h / Ambient temperature

3: 96 percent / Na, ammonia / tetrahydrofuran; ethanol / 1 h / -78 °C

With formic acid; ammonia; sodium; sodium iodide; 10% palladium on active carbon; In tetrahydrofuran; methanol; ethanol;

DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

(3R,6R)-1,4-Dibenzyl-5-hydroxy-3,6-bis-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazin-2-one → 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (137023-12-2)

Guidance literature:

Multi-step reaction with 4 steps

1: CF₃CO₂H / 36 h / Heating

2: 80.2 percent / formic acid / 10percentPd/C / methanol / 0.75 h / Ambient temperature

3: 90.1 percent / NaI / tetrahydrofuran / 2 h / Ambient temperature

4: 96 percent / Na, ammonia / tetrahydrofuran; ethanol / 1 h / -78 °C

With formic acid; ammonia; sodium; trifluoroacetic acid; sodium iodide; 10% palladium on active carbon; In tetrahydrofuran; methanol; ethanol;

DOI:10.1016/S0040-4020(01)86518-2

upstream raw materials:

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

Downstream raw materials:

2-<(2,4,5-Trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine