2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Base Information

Chemical Name:2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine
CAS No.:137023-10-0
Molecular Formula:C₃₃H₄₀N₂O₇
Molecular Weight:576.69
Hs Code.:

Synonyms:2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Chemical Property of 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Technology Process of 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

There total 4 articles about 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

: 137023-08-6
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

: 137023-10-0
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: With formic acid; 10% palladium on active carbon; In methanol; for 0.75h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: (3R,6R)-1,4-Dibenzyl-5-hydroxy-3,6-bis-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazin-2-one

: 137023-10-0
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃CO₂H / 36 h / Heating

2: 80.2 percent / formic acid / 10percentPd/C / methanol / 0.75 h / Ambient temperature

With formic acid; trifluoroacetic acid; 10% palladium on active carbon; In methanol;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 137023-07-5
1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

: 137023-10-0
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₂(OEt)2 / tetrahydrofuran / 1.5 h / -10 °C

2: CF₃CO₂H / 36 h / Heating

3: 80.2 percent / formic acid / 10percentPd/C / methanol / 0.75 h / Ambient temperature

With formic acid; lithium diethoxyaluminum hydride; trifluoroacetic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(01)86518-2