1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

Base Information

Chemical Name:1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione
CAS No.:137023-07-5
Molecular Formula:C₄₀H₄₆N₂O₈
Molecular Weight:682.814
Hs Code.:

Synonyms:1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

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Chemical Property of 1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

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Technology Process of 1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

There total 1 articles about 1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 100-39-0
benzyl bromide

: 137043-31-3
3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-piperazinedione

: 137023-07-5
1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 40 ℃; for 3h;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 137023-07-5
1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

: (3R,6R)-1,4-Dibenzyl-5-hydroxy-3,6-bis-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazin-2-one

Guidance literature:: With lithium diethoxyaluminum hydride; In tetrahydrofuran; at -10 ℃; for 1.5h;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 137023-07-5
1,4-Bis-(phenyl)methyl-3,6-bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione

: 112446-08-9,114030-15-8,115511-18-7,137120-99-1
2-<(2,4,5-Trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 6 steps

1: LiAlH₂(OEt)2 / tetrahydrofuran / 1.5 h / -10 °C

2: CF₃CO₂H / 36 h / Heating

3: 80.2 percent / formic acid / 10percentPd/C / methanol / 0.75 h / Ambient temperature

4: 90.1 percent / NaI / tetrahydrofuran / 2 h / Ambient temperature

5: 96 percent / Na, ammonia / tetrahydrofuran; ethanol / 1 h / -78 °C

6: 97.4 percent / AlH₃ / tetrahydrofuran / 1.5 h / Ambient temperature

With aluminium hydride; formic acid; ammonia; sodium; lithium diethoxyaluminum hydride; trifluoroacetic acid; sodium iodide; 10% palladium on active carbon; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/S0040-4020(01)86518-2