ethyl 2-nitrophenyl methylmalonate

Base Information

• Chemical Name: ethyl 2-nitrophenyl methylmalonate
• CAS No.: 24161-56-6
• Molecular Formula: C₁₂H₁₃NO₆
• Molecular Weight: 267.238
• Mol file: 24161-56-6.mol

Synonyms:ethyl 2-nitrophenyl methylmalonate

Chemical Property of ethyl 2-nitrophenyl methylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-nitrophenyl methylmalonate

There total 2 articles about ethyl 2-nitrophenyl methylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-chloroformylpropanoate (50496-34-9) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → ethyl 2-nitrophenyl methylmalonate (24161-56-6)

Guidance literature:

Multistep reaction; (i) NaOMe, MeOH, (ii) /BRN= 1759069/, Et₂O;

DOI:10.1021/ja01039a029

Reference yield:

potassium ethyl methylmalonate (103362-70-5) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → ethyl 2-nitrophenyl methylmalonate (24161-56-6)

Guidance literature:

With dicyclohexyl-carbodiimide; Ambient temperature;

DOI:10.1139/v86-190

Reference yield:

ethyl 2-nitrophenyl methylmalonate (24161-56-6) → ethanol (64-17-5) + methyl-propanedioic acid (516-05-2) + 2-hydroxynitrobenzene (88-75-5,78813-12-4)

Guidance literature:

With pH = 8.00; In water; at 23 ℃; under 750.06 Torr; Mechanism; Rate constant; pressure-dependence of rates of elimination; activation parameter for hydrolysis: ΔV(excit.); var. press.;

DOI:10.1039/P29880000557

upstream raw materials:

ethyl 2-chloroformylpropanoate

2-hydroxynitrobenzene

potassium ethyl methylmalonate

Downstream raw materials:

ethanol

methyl-propanedioic acid

2-hydroxynitrobenzene