7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide

Base Information

Chemical Name:7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide
CAS No.:1392841-58-5
Molecular Formula:C₁₇H₁₅N₃O₃
Molecular Weight:309.324
Hs Code.:

Synonyms:7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide

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Chemical Property of 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide

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Technology Process of 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide

There total 4 articles about 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-22-3
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 74-89-5
methylamine

: 1392841-58-5
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide

Guidance literature:: In tetrahydrofuran; ethanol; at 80 ℃; for 4h; Sealed tube;

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 1392841-58-5
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 80 °C

2.1: ethanol / 5 h / Reflux

3.1: pyridine; lithium iodide / 1 h / Reflux

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

4.2: 16 h / 20 °C

4.3: 16 h / 20 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium methylate / methanol

6.2: pH 4

7.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Sealed tube

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 174740-68-2
5-dimethylamino-3-ethoxycarbonyl-2-methoxycarbonyl-penta-2,4-dienoic acid methyl ester

: 1392841-58-5
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 5 h / Reflux

2.1: pyridine; lithium iodide / 1 h / Reflux

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

3.2: 16 h / 20 °C

3.3: 16 h / 20 °C

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol

5.2: pH 4

6.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Sealed tube

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;