(R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate

Base Information

• Chemical Name: (R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate
• CAS No.: 1364488-14-1
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 1364488-14-1.mol

Synonyms:(R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate

Chemical Property of (R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate

There total 2 articles about (R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-cyano-3-phenylpropyl dimethylcarbamate (1364488-04-9) + benzoyl chloride (98-88-4) → (R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate (1364488-14-1) + (S)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; at -114 ℃; for 0.0833333h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc00082b

Reference yield:

(S)-2-hydroxy-4-phenylbutyronitrile (53279-92-8,120999-41-9,121054-03-3,117213-74-8) → (R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate (1364488-14-1) + (S)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

1.2: 45.5 h / 0 - 25 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether / 0.08 h / -114 °C / Inert atmosphere

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1039/c2cc00082b

upstream raw materials:

(S)-1-cyano-3-phenylpropyl dimethylcarbamate

benzoyl chloride

(S)-2-hydroxy-4-phenylbutyronitrile