(S)-1-cyano-3-phenylpropyl dimethylcarbamate

Base Information

• Chemical Name: (S)-1-cyano-3-phenylpropyl dimethylcarbamate
• CAS No.: 1364488-04-9
• Molecular Formula: C₁₃H₁₆N₂O₂
• Molecular Weight: 232.282
• Mol file: 1364488-04-9.mol

Synonyms:(S)-1-cyano-3-phenylpropyl dimethylcarbamate

Chemical Property of (S)-1-cyano-3-phenylpropyl dimethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-cyano-3-phenylpropyl dimethylcarbamate

There total 1 articles about (S)-1-cyano-3-phenylpropyl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

bis(trichloromethyl) carbonate (32315-10-9) + (S)-2-hydroxy-4-phenylbutyronitrile (53279-92-8,120999-41-9,121054-03-3,117213-74-8) + dimethyl amine (124-40-3) → (S)-1-cyano-3-phenylpropyl dimethylcarbamate (1364488-04-9)

Guidance literature:

bis(trichloromethyl) carbonate; (S)-2-hydroxy-4-phenylbutyronitrile; With triethylamine; In diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

dimethyl amine; With triethylamine; In diethyl ether; at 0 - 25 ℃; for 45.5h; Inert atmosphere;

DOI:10.1039/c2cc00082b

Reference yield: 89.0%

(S)-1-cyano-3-phenylpropyl dimethylcarbamate (1364488-04-9) + benzyl bromide (100-39-0) → 2-cyano-1,4-diphenylbutan-2-yl dimethylcarbamate

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; at -114 ℃; for 0.0833333h; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc00082b

Reference yield: 73.0%

(S)-1-cyano-3-phenylpropyl dimethylcarbamate (1364488-04-9) + pivaloyl chloride (3282-30-2) → 3-cyano-5,5-dimethyl-4-oxo-1-phenylhexan-3-yl dimethylcarbamate

Guidance literature:

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -107 ℃; for 0.233333h; Inert atmosphere;

DOI:10.1002/anie.201303442

upstream raw materials:

bis(trichloromethyl) carbonate

(S)-2-hydroxy-4-phenylbutyronitrile

dimethyl amine

Downstream raw materials:

(R)-ethyl 2-cyano-2-((dimethylcarbamoyl)oxy)-4-phenylbutanoate

(R)-3-cyano-5,5-dimethyl-4-oxo-1-phenylhexan-3-yl dimethylcarbamate

(R)-2-cyano-1-oxo-1,4-diphenylbutan-2-yl dimethylcarbamate

(R)-3-cyano-5-methyl-4-oxo-1-phenylhexan-3-yl dimethylcarbamate