2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile

Base Information

Chemical Name:2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile
CAS No.:252022-35-8
Molecular Formula:C₃₂H₃₄N₂O
Molecular Weight:462.635
Hs Code.:

Synonyms:2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile

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Chemical Property of 2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile

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Technology Process of 2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile

There total 3 articles about 2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile

: 252022-35-8
2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Et₃N; CuBr / (Ph₃P)4Pd / 3 h / Heating

2: pyridine / CH₂Cl₂ / 20 h / 20 °C

3: K₂CO₃ / acetonitrile / 15 h / Heating

With pyridine; potassium carbonate; triethylamine; copper(I) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; acetonitrile; 1: Alkylation / 2: Mesylation / 3: Substitution;
DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

: 252022-33-6
2-[4-(4-Hydroxy-1-butynyl)phenyl]isobutyronitrile

: 252022-35-8
2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 20 h / 20 °C

2: K₂CO₃ / acetonitrile / 15 h / Heating

With pyridine; potassium carbonate; In dichloromethane; acetonitrile; 1: Mesylation / 2: Substitution;
DOI:10.1016/S0014-827X(99)00070-1