2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile

Base Information

• Chemical Name: 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile
• CAS No.: 394222-36-7
• Molecular Formula: C₃₂H₃₆N₂O₂
• Molecular Weight: 480.65

Synonyms:2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile

Chemical Property of 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile

There total 13 articles about 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (169280-06-2) + C18H21NO (115-46-8) → 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile (394222-36-7)

Guidance literature:

With lithium perchlorate; In toluene; at 150 ℃; for 4h; Reagent/catalyst; Temperature; Concentration; Solvent;

Reference yield: 63.0%

2-(4-(4-bromobutanoyl)phenyl)-2-methylpropanenitrile (394222-38-9) + C18H21NO (115-46-8) → 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (169280-06-2) + 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile (394222-36-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 25 ℃; for 8h;

DOI:10.1021/op100090j

Reference yield: 55.0%

4-(4-(2-cyanopropan-2-yl)phenyl)-4-oxobutyl 4-methylbenzenesulfonate (1252902-28-5) + C18H21NO (115-46-8) → 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (169280-06-2) + 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile (394222-36-7)

Guidance literature:

With triethylamine; In acetone; at 60 ℃;

DOI:10.1021/op100090j

upstream raw materials:

2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile

C₁₈H₂₁NO

2-(4-bromophenyl)-2-methylpropanenitrile

2-[4-(4-Hydroxy-1-butynyl)phenyl]isobutyronitrile

Downstream raw materials:

2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropionitrile

fexofenadine

fexofenadine sodium salt

fexofenadine hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 394222-36-7 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send